Our main research activities are involved with investigating intracellular signaling mechanisms that regulate ion transport across epithelial cells. Ion transport governs fluid movement across epithelial cells, an essential process for the normal functioning of mucosal surfaces such as those of the intestinal and respiratory tracts. Many pathological states are associated with dysregulated epithelial transport including cystic fibrosis, infectious diseases, and inflammatory bowel diseases.  However, there is currently a lack of specific therapies for such conditions. Currently our research employs electrophysiological, imaging, immunochemical, molecular and enzyme assay techniques to elucidate the intracellular signaling mechanisms that govern ion transport. The long-term goal is to gain new insights into epithelial physiology that will ultimately identify new strategies for the treatment of epithelial transport disorders.